2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cytochrome P450

Cytochrome P450

CYPs

Cytochrome P450

Related Products

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Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Isoform Specific Products:

Cytochrome P450 Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10493R
    Cobicistat (Standard)
    		Inhibitor
    Cobicistat (Standard) is the analytical standard of Cobicistat. This product is intended for research and analytical applications. Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.
    Cobicistat (Standard)
  • HY-163804
    Cyprocide-B
    		Modulator
    Cyprocide-B is activated by Cytochrome P450 and converted to electrophilic metabolites that selectively kill nematodes C. elegans. Cyprocide-B is promising for research of selective nematicide.
    Cyprocide-B
  • HY-135334S
    ACP-5862-d4
    		Inhibitor
    ACP-5862-d4 is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM.
    ACP-5862-d<sub>4</sub>
  • HY-13632S2
    Exemestane-d3
    		Inhibitor
    Exemestane-d3 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research.
    Exemestane-d<sub>3</sub>
  • HY-118216R
    Bitertanol (Standard)
    		Modulator
    Bitertanol (Standard) is the analytical standard of Bitertanol. This product is intended for research and analytical applications. Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an CYP1A1, CYP2B, and CYP3A inducer in vivo and an CYP1A inhibitor in vitro.
    Bitertanol (Standard)
  • HY-139382
    2-(Isopentylamino)naphthalene-1,4-dione
    		Inhibitor
    2-(Isopentylamino)naphthalene-1,4-dione (compound 3d), a Vitamin K (HY-B2172) analogue, shows protection in Pentylenetetrazole (PTZ)-induced seizure model. 2-(Isopentylamino)naphthalene-1,4-dione significantly increases ATP levels in zebrafish as well as HT-22 cells. 2-(Isopentylamino)naphthalene-1,4-dione shows excellent permeability into the brain.
    2-(Isopentylamino)naphthalene-1,4-dione
  • HY-155456
    CYP2A6-IN-1
    		Inhibitor
    CD-6 is a flavonoid CYP2A6 inhibitor (IC50: 1.566 μM). CYP2A6 inhibits the metabolism of nicotine to cotinine, resulting in an increase in the amount of nicotine available in the blood, leading to increased smoking behavior. CD-6 mediates CYP2A6 inhibition and can be used in research on smoking cessation or smoking-related diseases.
    CYP2A6-IN-1
  • HY-N0688R
    Linderane (Standard)
    		Inhibitor
    Linderane (Standard) is the analytical standard of Linderane. This product is intended for research and analytical applications. Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp.
    Linderane (Standard)
  • HY-W401407
    Diosmetin-3-O-glucuronide
    Diosmetin-3-O-glucuronide is a major circulating metabolite of Diosmetin (HY-N0125) in plasma and in urine. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity.
    Diosmetin-3-O-glucuronide
  • HY-145751
    7α-Hydroxy-DHEA
    7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma.
    7α-Hydroxy-DHEA
  • HY-17643R
    Oteseconazole (Standard)
    		Inhibitor
    Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes.
    Oteseconazole (Standard)
  • HY-178340
    Antifungal agent 137
    		Inhibitor
    Antifungal agent 137 (Compound 4S) is an antifungal agent. Antifungal agent 137 inhibits Phomopsis sp. (PS), with an EC50 of 0.15 μg/mL. Antifungal agent 137 inhibits lanosterol 14α-demethylase (CYP51), with an IC50 of 5.00 μg/mL. Antifungal agent 137 disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces an increase in intracellular ROS levels, triggering oxidative stress. Antifungal agent 137 can be used for the study of fungal infection.
    Antifungal agent 137
  • HY-170920
    Herbicide safener-4
    		Activator
    Herbicide safener-4 (Compound I-15) is a Herbicide safener, improving the herbicide resistance of crops without reducing the herbicidal effect on targeted weed species. Herbicide safener-4 competitively binds to the ALS active site with Mesosulfuron-methyl (HY-126987). Herbicide safener-4 enhances GSH (HY-D0187), GST, CYP450, POD, SOD and ALS activity in plants.
    Herbicide safener-4
  • HY-14874R
    Topiroxostat (Standard)
    		Inhibitor
    Topiroxostat (Standard) is the analytical standard of Topiroxostat. This product is intended for research and analytical applications. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.
    Topiroxostat (Standard)
  • HY-17367R
    Atazanavir (Standard)
    		Inhibitor
    Atazanavir (Standard) is the analytical standard of Atazanavir. This product is intended for research and analytical applications. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death.
    Atazanavir (Standard)
  • HY-N9508R
    Perilla ketone (Standard)
    Perilla ketone is a naturally occurring xenobiotic compound. Perilla ketone is activated by pulmonary P450 cytochrome enzymes in the lung, resulting in severe pulmonary damage and development of diffuse pulmonary edema.
    Perilla ketone (Standard)
  • HY-A0016S3
    Dronedarone-d6
    		Inhibitor
    Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
    Dronedarone-d<sub>6</sub>
  • HY-N5092R
    7-Methylcoumarin (Standard)
    7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem.
    7-Methylcoumarin (Standard)
  • HY-103389R
    1-Aminobenzotriazole (Standard)
    		Inhibitor
    1-Aminobenzotriazole (Standard) is the analytical standard of 1-Aminobenzotriazole. This product is intended for research and analytical applications. 1-Aminobenzotriazole is a nonspecific and irreversible inhibitor of cytochrome P450 (P450).
    1-Aminobenzotriazole (Standard)
  • HY-N0370R
    Bergapten (Standard)
    		Inhibitor
    Bergapten (Standard) is the analytical standard of Bergapten. This product is intended for research and analytical applications. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.
    Bergapten (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Cytochrome P450 Isoform Comparison

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